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Vitamin c melatonin

The ameliorating effects of melatonin and vitamin C plus vitamin E were examined histologically and biochemically in lung tissues in rats exposed to chlorpyriphos-ethyl CE. Tissue samples of lungs were taken by using appropriate techniques for biochemical and histological examinations under anesthesia at the twenty-fourth hours of CE administration, at the end of the sixth day of the experiment.

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The ethiopathogenesis of tympanosclerosis has not been completely under- stood yet. Recent studies have shown that free oxygen radicals are important in the formation of tympanosclerosis. Melatonin and Vitamin C are known to be a powerful antioxidant, interacts directly with Reactive Oxygen Species and controls free radical-mediated tissue damage. To demonstrate the possible preventative effects of melatonin and Vitamin C on tympanosclerosis in rats by using histopathology and determination of total antioxidant status total antioxidant status.

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Try out PMC Labs and tell us what you think. Learn More. Melatonin can eliminate free radicals and this function can be intensified byvitamin C. Melatonin and vitamin C can have synergic antioxidant effects. The aim of thisstudy was to investigate the effects of adjunctive use of melatonin and vitamin C in the non-surgical treatment of chronic periodontitis. Therefore adjunctive dose of vitamin C offered an additional effect at this interval. Combination therapy with melatonin and vitamin C can improve the of non-surgical periodontal therapy.

Introduction

Melatonin is a neuroendocrine hormone which is released by the hypophysis with a circadian rhythm and a higher blood level at night. Also, its anti-neoplastic and protective characteristics are of great importance. An important feature of periodontitis is production of free oxygen radicals which are released by bacteria and also, host immune response. An imbalance between anti-oxidants and pro-oxidants may lead to a remarkable tissue breakdown. They found that melatonin levels of plasma and saliva increase in diabetic patients with remarkable destruction. They suggested that melatonin increase during diabetes may have a protective role in the periodontium.

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Vitamin C has been suggested as a host modulatory agent in periodontal treatment. Vitamin C is important in the synthesis of intercellular substance like collagen fibers; 15 it also has an immune modulatory function. Since an imbalance between free radicals and oxidants can play a major role in chronic melatonin and given the role of melatonin in the elimination of free radicals and synergic function of vitamin C and melatonin, 18 the aim of the present research was to investigate the effects of simultaneous use of melatonin and vitamin C in the non-surgical treatment of chronic periodontitis.

All the subjects were systemically healthy. Subjects were excluded from the study if 1 they had a prior use of non-steroidal anti-inflammatory drugs or antimicrobial drugs in the last 3 months before the study began; 2 they were lactating or pregnant; 3 they had used mouthwashes or vitamin supplements in the last 3 months before the research; 4 they had a history of current or smoking or recreational drug use; and 5 they had special dietary requirements.

Sixty volunteers with moderate-to-severe chronic periodontitis, each with at least three 5—7-mm-deep pockets were selected for this study. The subjects were categorized into three groups. The subjects completed medical and dental questionnaires and the study protocol was approved by the Ethics Committee of Tabriz University of Medical Sciences, Tabriz, Iran. After enrollment, all the subjects were instructed melatonin toothbrushing with modified bass technique and also flossing twice a day and then the groups were randomly further divided into three groups using a randomization software.

Periodontal therapy was conducted by a single periodontist MC. Clinical examinations were carried out by a single vitamin MF who was an experienced periodontist and blinded to the type of treatment. Clinical indices were obtained at four surfaces per tooth: mesiofacial, buccal, distofacial and lingual. PD and CAL were recorded in duplicate, and when the difference between the measurements was 1 mm, a third evaluation was carried out and the vitamin measurement of each site was calculated from the closest two of the triplicate probing measures.

Gingival index GI was also assessed. The SPSS The mean GI of the study groups at baseline and 3 and 6 months after treatment are presented in Table 1. Therefore the adjunctive dose of vitamin C offered an additional effect at this interval.

The periodontal disease is an inflammatory process in which the bone and periodontal ligament are destroyed via a restorative process by osteoclasts. Cytokines and local factors secreted by host defense cells in response to bacterial attack mediate this process.

Melatonin plays a critical role in the regulation of this protein-mediated process. In the present study we found that the combined use of vitamin C and melatonin supplements with non-surgical periodontal therapy in periodontitis with more than 5 mm pockets ificantly reduced the amount of Melatonin and CAL compared to scaling alone. Improvements in these clinical parameters following non-surgical periodontal treatment are parallel to the findings in this regard but the differences in the scores can be attributed to the adjunctive use of melatonin and vitamin C.

Cutandoet al 20 reported the same in diabetic patients with chronic periodontitis. The greater improvements in a study by Cutandoet al 20 compared to present study can be attributed to the local use of melatonin. Animal studies and clinical trials have documented therapeutic effects of melatonin. In addition, at 6-month postoperative interval differences in PD and CAL scores were statistically ificant compared to 3-month interval vitamin the difference in the same interval in PD and CAL were not statistically ificant in the two other groups.

This can be attributed to the long-term effects of combination therapy with melatonin and vitamin C as a host-modulatory agent but the role of vitamin C deficiency in periodontitis isunknown. Abou Sulaiman et al 28 reported that adjunctive use of vitamin C did not improve the clinical parameters compared to non-surgical periodontal treatment alone.

The positive effect of melatonin C in our study can be attributed to the synergic effect of melatonin and vitamin C. The reason for this increase in synergic function may be the fact that vitamin C recycles melatonin. Combination of these two supplements showed better effects in the long term. The authors would like to acknowledge the Dental and Periodontal Research Center at Tabriz University of Medical Sciences for the financial support of this project.

The study was planned by MC and MH. The statistical analyses and interpretation of data were carried out by MS. All the authors have read and approved the final manuscript. National Center for Biotechnology InformationU. Published online Dec Author information Article notes Copyright and information Disclaimer. Received Dec 24; Accepted Aug This article has been cited by other articles in PMC. Abstract Background. Keywords: Dental scaling, melatonin, periodontitis, vitamin C. Introduction Melatonin is a neuroendocrine hormone which is released by the hypophysis with a circadian rhythm and a higher blood level at vitamin.

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Table 1 Comparison of GI at different observation periods in different groups. Open in a separate window. Table 2 Comparison of PD at different observation periods in different groups. Table 3 Comparison of CAL at different observation periods in different groups. Discussion The periodontal disease is an inflammatory process in which the bone and periodontal ligament are destroyed via a restorative process by osteoclasts. Acknowledgments The authors would like to acknowledge the Dental and Periodontal Research Center at Tabriz University of Medical Sciences for the financial support of this project.

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References 1. Melatonin in pathogenesis and therapy of cancer. Indian J Med. Relationship between salivary melatonin and severity of periodontal disease. J periodontal. The physiology and pharmacology of melatonin in humans.

Horm Res. Melatonin and its role in oxidative stress related diseases of oral cavity. J Physiol Pharmacol. J Pineal Res. Melatonin: reducing molecular pathology and dysfunction due to free radicals and associated reactants. Neuro Endocrinol Lett. Mol Med. Melatonin : potential function in the oral cavity. Salivary and gingival crevicular fluid melatonin in periodontal health and disease. J Periodontol. The effect of ascorbic acid supplementation on periodontal tissue ultrastructure in subjects with progressive periodontitis.

Int J VitNutr Res. Dietary vitamin C and the risk for periodontal disease. Ascorbic acid requirements in post-operative patients. SurgGynecol Obstet. Rubin MB. Vitamin and wound healing.

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Plast Surg-Nurs. Exton-Smith, A. In: T. Theimportance of vitamins to human health. United Kingdom:Lancaster; J Investig Dermatol.

Bhaskaram P. Micronutrient malnutrition, infection, and immunity: an overview. Nutrients and their role in host resistance to infection.

J Leukoc Biol. Individual and synergistic antioxidative actions of melatonin: studies with vitamin E, vitamin C, glutathione and desferrioxamine desferoxamine in rat liver homogenates. J Pharm Pharmacol. Int J Mol Med. J ClinExp Dent. Anti-fibrotic and anti-inflammatory properties of melatonin on human gingival fibroblasts in vitro.